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Science 3 January 1969:
Vol. 163. no. 3862, pp. 75 - 78
DOI: 10.1126/science.163.3862.75
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Articles

Macroglobulin Structure: Homology of Mu and Gamma Heavy Chains of Human Immunoglobulins

Maurice Wikler 1, Heinz Köhler 1, Tomotaka Shinoda 1, and F. W. Putnam 1

1 Division of Biological Sciences, Indiana University, Bloomington 47401

The amino acid sequence of fragments obtained by cyanogen bromide cleavage of the mu-chain of a human ggrM-globulin is homologous to the NH2-terminal sequences of the gamma-chain of human and rabbit ggrG-globulins and is related to that of human light chains. This supports the hypothesis that light and heavy chains evolved from a common ancestral gene.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Amino acid sequence homology between histone H5 and murine leukemia virus phosphoprotein p12.
L. Henderson, R. Gilden, and S Oroszlan (1979)
Science 203, 1346-1348
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Complete Amino Acid Sequence of the Mu Heavy Chain of a Human IgM Immunoglobulin.
F. W. Putnam, G. Florent, C. Paul, T. Shinoda, and A. Shimizu (1973)
Science 182, 287-291
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Variation and Homology in the Mu and Gamma Heavy Chains of Human Immunoglobulins.
A. Shimizu, C. Paul, H. Kohler, T. Shinoda, and F. W. Putnam (1971)
Science 173, 629-633
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Structure of the Hinge Region of the Mu Heavy Chain of Human IgM Immunoglobulins.
C. Paul, A. Shimizu, H. Kohler, and F. W. Putnam (1971)
Science 172, 69-72
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Macroglobulin Structure: Variable Sequence of Light and Heavy Chains.
H. Kohler, A. Shimizu, C. Paul, and F. W. Putnam (1970)
Science 169, 56-59
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