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Science 27 December 1968:
Vol. 162. no. 3861, pp. 1495 - 1496
DOI: 10.1126/science.162.3861.1495
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Articles

Sterol Precursors of Cholesterol in Adult Human Brain

Giovanni Galli 1, Enrica Grossi Paoletti 1, and Joseph F. Weiss 1

1 Institute of Pharmacology, University of Milan, 20129 Milan, Italy

Adult human brain contains cholestanol and two series of cholesterol precursors having 30, 29, 28, and 27 carbon atoms; one has an unsaturated steroid nucleus, and the other is unsaturated in both nucleus and side chain. The ability of preparations of brain to incorporate a specific precursor into cholesterol, as well as into these sterol metabolites in vitro, indicates that cholesterol synthesis continues long after brain maturation ceases.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)