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Science 27 December 1968:
Vol. 162. no. 3861, pp. 1493 - 1494
DOI: 10.1126/science.162.3861.1493
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Articles

Warfarin Treatment of Mice Bearing Autochthonous Tumors: Effect on Spontaneous Metastases

James J. Ryan 1, Alfred S. Ketcham 1, and Hilda Wexler 1

1 National Cancer Institute, Bethesda, Maryland 20014

Long-term oral administration of sodium warfarin significantly reduced the incidence of spontaneous metastases in the lungs from 83 percent in controls to 8 percent in treated C57/BL/6N mice. The size and weight of primary tumors in mice treated with warfarin were less than in control mice. Length of survival was unaffected.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)