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Science 27 December 1968:
Vol. 162. no. 3861, pp. 1484 - 1485
DOI: 10.1126/science.162.3861.1484
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Articles

Inhibition of Cell Growth in vitro by Adenosine 3', 5'-Monophosphate

Wayne L. Ryan 1 and Margaret L. Heidrick 1

1 Departments of Biochemistry and Obstetrics and Gynecology, University of Nebraska College of Medicine, Omaha

Adenosine 3',5'-monophosphate, at a concentration of 40 micrograms per milliliter, inhibits the growth of HeLa and strain L cells in culture. The inhibition becomes progressively greater during the incubation of the cells. Adenosine 5'-monophosphate and adenosine, metabolites of adenosine 3',5'-monophosphate, do not affect the growth of either cell culture. This suggests that 3',5'-monophosphate enters the cell without alteration. Dibutyryl-adenosine 3',5'-monophosphate, reported to have a greater activity than adenosine 3'5'-monophosphate on several tissues, inhibited the growth of the cells much less.


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