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Science 13 December 1968:
Vol. 162. no. 3859, p. 1287
DOI: 10.1126/science.162.3859.1287
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Articles

Hemin: An Inhibitor of Erythroid Cell Ribonuclease

Edward R. Burka 1

1 Cardeza Foundation for Hematologic Research, Jefferson Medical College, Philadelphia, Pennsylvania 19107

Hemin, in concentrations which stimulate protein synthesis and stabilize polyribosomes in reticulocytes, is a potent inhibitor of ribonuclease activity in the erythroid cell. This may offer a partial explanation for the way in which hemin acts to accelerate globin synthesis and thus synchronize the synthesis of hemin and globin in the maturing erythroid cell.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Role of Ribosomal Subunits in Mammalian Cells.
C. Baglioni, C. Vesco, and M. Jacobs-Lorena (1969)
Cold Spring Harb Symp Quant Biol 34, 555-565
   Abstract »    PDF »
Translational Control in Hemoglobin Synthesis.
M. Rabinovitz, M. L. Freedman, J. M. Fisher, and C. R. Maxwell (1969)
Cold Spring Harb Symp Quant Biol 34, 567-578
   Abstract »    PDF »


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