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Science 13 December 1968:
Vol. 162. no. 3859, pp. 1279 - 1281
DOI: 10.1126/science.162.3859.1279
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Articles

Human Osteosarcomas: Immunologic Evidence Suggesting an Associated Infectious Agent

Donald L. Morton 1 and Richard A. Malmgren 2

1 Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
2 Pathologic Anatomny Branch, National Cancer Institute

Immunofluorescent studies have revealed a high incidence of antibodies to osteosarcomas in the serums of patients with this disease and their close associates which react with a common antigen (or antigens) in osteosarcomas. The distribution of these antibodies suggests the association of an infectious agent with this neoplasm which is capable of producing unrecognized infections in healthy contacts of these patients.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Skeletal and Soft Tissue Sarcomas: Treatment With Adjuvant Immunotherapy.
C. M. Townsend Jr, F. R. Eilber, and D. L. Morton (1976)
JAMA 236, 2187-2189
   Abstract »    PDF »
Transfer Factor: Potential for Therapy of Malignant Diseases.
J. A. Neidhart and A. F. LoBuglio (1975)
Arch Otolaryngol Head Neck Surg 101, 664-666
   Abstract »    PDF »
Evidence for in vivo Reaction of Antibody and Complement to Surface Antigens of Human Cancer Cells.
K. Irie, R. F. Irie, and D. L. Morton (1974)
Science 186, 454-456
   Abstract »    PDF »
Evidence for Fetal Antigen in Human Sarcoma.
B. Mukherji and Y. Hirshaut (1973)
Science 181, 440-442
   Abstract »    PDF »
Hereditary Bone Dysplasia with Sarcomatous Degeneration: Study of a Family.
W. H. ARNOLD (1973)
Ann Intern Med 78, 902-906
   Abstract »    PDF »
Immunodeficiency Disease and Malignancy: Various Immunologic Deficiencies of Man and the Role of Immune Processes in the Control of Malignant Disease.
T. A. WALDMANN, W. STROBER, and R. M. BLAESE (1972)
Ann Intern Med 77, 605-628
   Abstract »    PDF »
Immunological Studies on Urinary Bladder Tumors of Rats and Mice.
L. A. Taranger, W. H. Chapman, I. Hellstrom, and K. E. Hellstrom (1972)
Science 176, 1337-1340
   Abstract »    PDF »
Leukemia-associated antigens in the mixed leukocyte culture test..
M. L. Bach, F. H. Bach, and P. Joo (1969)
Science 166, 1520-1522
   Abstract »    PDF »
Human Liposarcomas: Tissue Cultures Containing Foci of Transformed Cells with Viral Particles.
D. L. Morton, W. T. Hall, and R. A. Malmgren (1969)
Science 165, 813-815
   Abstract »    PDF »


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