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Science 29 November 1968:
Vol. 162. no. 3857, pp. 999 - 1001
DOI: 10.1126/science.162.3857.999
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Articles

Tyrosine Transaminase: Development of Daily Rhythm in Liver of Neonatal Rat

Eva Honova 1, Sanford A. Miller 1, Richard A. Ehrenkranz 1, and Anna Woo 1

1 Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge 02139

The development of the 24-hour rhythm in tyrosine transaminase activity was studied in the liver of the neonatal rat. A recognizable rhythm appears within 48 hours after birth, but it is opposite in phase to that observed in the adult rat. The reversal of the adult pattern occurs 21 to 23 days after birth and may represent a response to a change both in the eating pattern and in the amount of protein eaten.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)