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Science 29 November 1968:
Vol. 162. no. 3857, pp. 1007 - 1009
DOI: 10.1126/science.162.3857.1007-a
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Articles

Activation of Hageman Factor by L-Homocystine

Oscar D. Ratnoff 1

1 Department of Medicine, Case Western Reserve University School of Medicine, and University Hospitals of Cleveland, Cleveland, Ohio 44106

L-Homocystine activates Hageman factor, as demonstrated by its capacity to initiate clotting and to induce the evolution of plasma kinins. Perhaps, strategically located deposits of this amino acid are responsible for the unusual frequency of thrombosis in patients with homocystinuria.


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Hyperhomocysteinemia and Venous Thrombosis.
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State-of-the-Art Review: Vascular Thrombohemorrhagic Disorders: Hereditary and Acquired.
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Clinical and Applied Thrombosis/Hemostasis 7, 178-194
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Interaction of Drugs and Nutrients.
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JAMA 214, 137-138
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Low-Methionine Diet Treatment of Homocystinuria.
R. N. SCHIMKE (1969)
Ann Intern Med 70, 642-643
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