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Science 22 November 1968:
Vol. 162. no. 3856, pp. 907 - 908
DOI: 10.1126/science.162.3856.907
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Articles

Chemical Carcinogenesis: Persistence of Bound Forms of 2-Fluorenylacetamide

Sheldon M. Epstein 1, John McNary 1, Barbara Bartus 1, and Emmanuel Farber 1

1 Department of Pathology and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213

The persistent binding of metabolites of hepatic carcinogen, 2-fluorenylacetamide, to glycogen and to DNA in a new population of liver cells, hyperplastic nodules, and to glycogen in liver cancer cells weeks to months after the carcinogen was removed from the animals' diet is indicated by spectrophotometric, chromatographic, and mass spectrographic data. This persistence of binding does not appear to occur in the nonhyperplastic or nonneoplastic liver surrounding the nodules or the cancer.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Growth in vitro of Cells from Hyperplastic Nodules of Liver Induced by 2-Fluorenylacetamide or Aflatoxin B1.
M. Slifkin, L. P. Merkow, M. Pardo, S. M. Epstein, J. Leighton, and E. Farber (1970)
Science 167, 285-287
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Science. ISSN 0036-8075 (print), 1095-9203 (online)