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Science 8 November 1968:
Vol. 162. no. 3854, pp. 698 - 699
DOI: 10.1126/science.162.3854.698
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Articles

Noncycling Tumor Cells: Mitogenic Response to Antilymphocytic Serum

Jerome J. DeCosse 1 and Seymour Gelfant 2

1 Department of Surgery, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106
2 Department of Zoology, Syracuse University, Syracuse, New York 13210

After continuous labeling with tritiated thymidine for a period several times the cell generation time, some ELD ascites cells remained unlabeled. Despite continued exposure to tritiated thymidine, unlabeled mitoses appeared promptly after administration of mouse antilymphocytic serum. Immunosuppression released some noncycling G2 tumor cells into mitosis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Aging: Noncycling Cells an Explanation: Cell and tissue aging is the result of transitions from cycling to noncycling cells.
S. Gelfant and J. G. Smith Jr. (1972)
Science 178, 357-361
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Science. ISSN 0036-8075 (print), 1095-9203 (online)