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Science 8 November 1968:
Vol. 162. no. 3854, pp. 694 - 695
DOI: 10.1126/science.162.3854.694
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Articles

Amyloidosis Induced in Mice by Escherichia coli Endotoxin

Werner F. Barth 1, Joyce K. Gordon 1, and James T. Willerson 1

1 Arthritis and Rheumatism Branch, National Institute of Arthritis and Metabolic Diseases, Bethesda, Maryland

Amyloidosis was produced in mice by repeated subcutaneous injections of 0.5-or 0.005-milligram amounts of Escherichia coli endotoxin. Of the two strains of mice examined, amyloidosis was induced more readily in one than in the other. The ability of endotoxin to induce amyloidosis lends support to the view that stimulation of reticuloendothelial cells leads to amyloid formation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Repeated Immunization: Possible Adverse Effects: Reevaluation of Human Subjects at 25 Years.
C. S. WHITE III, W. H. ADLER, and V. G. McGANN (1974)
Ann Intern Med 81, 594-600
   Abstract »    PDF »
Pathogenesis of Amyloidosis.
A. S. COHEN (1969)
Ann Intern Med 70, 418-419
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)