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Science 8 November 1968:
Vol. 162. no. 3854, pp. 689 - 690
DOI: 10.1126/science.162.3854.689
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Articles

Red-Cell Transport Defect in Patients with Cystic Fibrosis and in Their Parents

J. W. Balfe 1, C. Cole 1, and L. G. Welt 1

1 Department of Medicine, University of North Carolina, School of Medicine, Chapel Hill 27514

The ouabain-sensitive and the ethacrynic acid-sensitive sodium efflux from erythrocytes of patients with cystic fibrosis are both decreased. Furthermore, the ouabain-sensitive adenosine triphosphatase activity is diminished in the red blood cell ghosts of these patients. Perhaps of greater significance is the fact that ethacrynic acid-sensitive sodium efflux is clearly diminished in the erythrocytes of the asymptomatic parents of these sick children. This defect in sodium transport may be valuable for detecting the heterozygous carrier state.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Pathological Alterations of Cation Movements in Red Blood Cells.
J. C. Parker and L. G. Welt (1972)
Arch Intern Med 129, 320-332
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