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Science 1 November 1968:
Vol. 162. no. 3853, pp. 576 - 578
DOI: 10.1126/science.162.3853.576
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Articles

Erythromycin-Resistant Mutant of Escherichia coli with Altered Ribosomal Protein Component

Kentaro Tanaka 1, Hiroshi Teraoka 1, Mikio Tamaki 1, Eiko Otaka 2, and Syozo Osawa 2

1 Shionogi Research Laboratory, Shionogi and Co., Ltd., Fukushima-kt, Osaka, Japan
2 Research Institute for Nuclear Medicine and Biology, Hiroshima University, Kasumi-cho, Hiroshima, Japan

Erythromycin combines with 50S ribosomal subunit of an erythromycin-sensitive Escherichia coli (strain Q13), while ribosomes from an erythromycin-resistant mutant from this strain have little affinity for the antibiotic. A protein component of the 50S subunit of the mutant strain is distinct from that of the parent Q13 strain.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Genetics of Ribosomes in Bacillus subtilis.
I. Smith, C. Goldthwaite, and D. Dubnau (1969)
Cold Spring Harb Symp Quant Biol 34, 85-89
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