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Science 25 October 1968:
Vol. 162. no. 3852, pp. 466 - 467
DOI: 10.1126/science.162.3852.466
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Articles

Evoked Release of Norepinephrine and Serotonin from Brain Slices: Inhibition by Lithium

Richard I. Katz 1, Thomas N. Chase 1, and Irwin J. Kopin 1

1 Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014

Slices of mammalian brain accumulate H3-norepinephrine and H3-serotonin when incubated in a physiologic medium containing these tritiated monoamines. When these tissues are subjected to mild electrical stimulation of short duration, which is associated with depolarization of nerve membranes, a striking increase in the rate of efflux of the exogenous labeled monoamines occurs. Stimulation-induced release of both labeled monoamines is diminished by the presence of lithium ions in the perfusing medium; related monovalent cations had no such effect. Evoked release from slices of brain from animals treated intraperitoneally with lithium chloride for 3 days was also reduced.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Mechanisms of Action of Lithium: I. Effects on Serotoninergic and Noradrenergic Systems in Normal Subjects.
H. K. Manji, J. K. Hsiao, E. D. Risby, J. Oliver, M. V. Rudorfer, and W. Z. Potter (1991)
Arch Gen Psychiatry 48, 505-512
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Lithium increases serotonin release and decreases serotonin receptors in the hippocampus.
S. Treiser, C. Cascio, T. O'Donohue, N. Thoa, D. Jacobowitz, and K. Kellar (1981)
Science 213, 1529-1531
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Medical treatment of mental illness.
P. Berger (1978)
Science 200, 974-981
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The Switch Process in Manic-Depressive Psychosis.
W. E. BUNNEY Jr., T. R. WEHR, J. C. GILLIN, R. M. POST, F. K. GOODWIN, and D. P. van KAMMEN (1977)
Ann Intern Med 87, 319-335
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Short- and Long-Term Lithium Administration: Effects on the Brain's Serotonergic Biosynthetic Systems.
S. Knapp and A. J. Mandell (1973)
Science 180, 645-647
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The "Switch Process" in Manic-Depressive Illness: II. Relationship to Catecholamines, REM Sleep, and Drugs.
W. E. Bunney Jr., F. K. Goodwin, D. L. Murphy, K. M. House, and E. K. Gordon (1972)
Arch Gen Psychiatry 27, 304-309
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Rubidium and Lithium: Opposite Effects on Amine-Mediated Excitement.
B. J. Carroll and P. T. Sharp (1971)
Science 172, 1355-1357
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Brain Norepinephrine: Enhanced Turnover after Rubidium Treatment.
J. M. Stolk, W. J. Nowack, J. D. Barchas, and S. R. Platman (1970)
Science 168, 501-503
   Abstract »    PDF »
Lithium-Carbonate Treatment in Depression and Mania: A Longitudinal Double-Blind Study.
F. K. Goodwin, D. L. Murphy, and W. E. Bunney Jr. (1969)
Arch Gen Psychiatry 21, 486-496
   Abstract »    PDF »


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