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Science 18 October 1968:
Vol. 162. no. 3851, pp. 359 - 360
DOI: 10.1126/science.162.3851.359
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Articles

Multiple Forms of Bacterial NADP-Specific Isocitrate Dehydrogenase

Henry C. Reeves 1, Bette Ann Brehmeyer 1, and Samuel J. Ajl 1

1 Department of Biochemistry, Albert Einstein Medical Center, Philadelphia, Pennsylvania 19141

Electrophoretically distinct forms of nicotinamide adenine dinucleotide phosphate-specific isocritrate dehydrogenase have been observed in extracts of Escherichia coli grown under different culture conditions. In glucose-grown cells, two distinct bands of isocitrate dehydrogenase activity were observed on polyacrylamide gels and have been completely resolved by employing ion-exchange chromatography. These multiple forms of the enzyme have been studied and their possible metabolic role is discussed.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)