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Science 11 October 1968:
Vol. 162. no. 3850, pp. 277 - 278
DOI: 10.1126/science.162.3850.277
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Articles

Brain Serotonin Concentration: Elevation Following Intraperitoneal Administration of Melatonin

Fernando Anton-Tay 1, Chuan Chou 1, Sylvia Anton 1, and Richard J. Wurtman 1

1 Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge 02139

The intraperitoneal administration of melatonin to rats caused an increase in brain serotonin concentration, especially in the midbrain. This effect could be demonstrated within 20 minutes of melatonin administration and was not associated with changes in norepinephrine concentration.


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