Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 27 September 1968:
Vol. 161. no. 3848, pp. 1361 - 1362
DOI: 10.1126/science.161.3848.1361
Prev | Table of Contents | Next

Articles

Induction of Collagenolytic and Proteolytic Activities in Rat and Human Fibroblasts by Anti-Inflammatory Drugs

J. C. Houck 1 and V. K. Sharma 1

1 Biochemical Research Laboratory, Children's Hospital, Washington, D.C., and Department of Pediatrics, George Washington University Medical School, Washington, D.C.

Confluent monolayers of either mouse or diploid human fibroblasts contained no measurable amounts of either collagenolytic (pH 5.5) or proteolytic (pH 7.5) activities. Within a few hours after exposure of these cells to antiinflammatory drugs, significant amounts of these enzymatic activities were demonstrable extracellularly. These activities were profoundly decreased in cultures simultaneously treated with the anti-inflammatory drugs and cycloheximide or actinomycin D.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Preliminary Evidence of Periodontal Disease in Lemmus trimucronatus Skulls from Northern Alaska.
C. L. Shalla (1972)
Journal of Dental Research 51, 1075-1079
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)