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Science 13 September 1968:
Vol. 161. no. 3846, pp. 1149 - 1151
DOI: 10.1126/science.161.3846.1149
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Articles

Inherited C'2 Deficiency in Man: Lack of Immunochemically Detectable C'2 Protein in Serums from Deficient Individuals

Margaret J. Polley 1

1 Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037

Monospecific antiserum to highly purified second component of human complement (C'2) was used to show the absence of the protein from the serums of four persons homozygous for a hereditary deficiency of second-component activity. Serum from an individual heterozygous for the deficiency contained a reduced amount of this protein as compared to the concentration in normal serum. These observations indicate that genetic deficiency of this component is due to failure of synthesis of normal amounts of the protein rather than to synthesis of an antigenically related, hemolytically inactive analog of C'2.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)