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Science 13 September 1968:
Vol. 161. no. 3846, pp. 1146 - 1147
DOI: 10.1126/science.161.3846.1146
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Articles

Thiobases in Escherchia coli Transfer RNA: 2-Thiocytosine and 5-Methylaminomethyl-2-thiouracil

John Carbon 1, Harold David 1, and Martin H. Studier 2

1 Molecular Biology Department, Abbott Laboratories, North Chicago, Illinois
2 Chemistry Division, Argonne National Laboratory, Argonne, Illinois

Two new sulfur-containing pyrimidine nucleotides have been isolated from hydrolyzates of Escherichia coli transfer RNA. The structures, 2-thiocytosine and 5-methylaminomethyl-2-thiouracil, have been assigned to the bases as a result of study of ultraviolet and mass spectra. An acid-degradation product, S-methylamino-methyluracil, has been synthesized and is identical to that derived from the natural product.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)