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Science 6 September 1968:
Vol. 161. no. 3845, pp. 1016 - 1017
DOI: 10.1126/science.161.3845.1016
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Articles

Copper: Relation to Pencillamine-Iduced Defect in Collagen

Israeli A. Jaffe 1, Parvin Merriman 1, and David Jacobus 1

1 Department of Medicine, New York Medical College, New York, and Walter Reed Army Institute for Research, Washington, D.C. 20012

When rats were depleted of copper by administration of a copperdeficient diet, no abnormalities developed in dermal collagen. In contrast, marked changes were produced by penicillamine although the degree of copperdeficiency induced by the drug was less. Large additions of copper to the diet failed to prevent the penicillamine-induced collagen defect when the drug was given parenterally. The effect of penicillamine on soft-tissue collagen appears to be unrelated to its copper-chelating properties.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)