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Science 30 August 1968:
Vol. 161. no. 3844, pp. 902 - 903
DOI: 10.1126/science.161.3844.902
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Articles

Histamie Release in vitro: Inhibition by Catecholamines and Methylxanthines

L. M. Lichtenstein 1 and S. Margolis 1

1 Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

Methylxanthines and catecholamines both inhibit antigenically induced histamine release from human leukocytes. They act synergistically to inhibit the reaction, but must be present when antigen is added; preincubation is not effective. Since both increase cellular levels of cyclic 3 ', 5'-adenosine monophosphate it is postulated that this compound plays a role in the regulation of allergic histamine release.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)