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Science 23 August 1968:
Vol. 161. no. 3843, pp. 804 - 806
DOI: 10.1126/science.161.3843.804
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Articles

Interferon: Protection of Cells Infected with an Intracellular Protozoan (Toxoplasma gondii)

Jack S. Remington 1 and Thomas C. Merigan 2

1 Palo Alto Medical Research Foundation and Division of Infectious Diseases, Stanford University School of Medicine, Palo Alto, California 94301
2 Division of Infectious Diseases, Stanford University School of Medicine

Chick and mouse cell monolayers treated with interferon were significantly protected from destruction by toxoplasma. The results suggest that fewer numbers of organisms were released from interferon-treated cells. Interferons were uniformly more active in a viral assay than in a toxoplasma assay, and they had the same properties in both assays. The data suggest that interferon activity may be directed against organisms phylogenetically higher than viruses.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Exacerbated Susceptibility to Infection-Stimulated Immunopathology in CD1d-Deficient Mice.
S. T. Smiley, P. A. Lanthier, K. N. Couper, F. M. Szaba, J. E. Boyson, W. Chen, and L. L. Johnson (2005)
J. Immunol. 174, 7904-7911
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Effector Cells of Both Nonhemopoietic and Hemopoietic Origin Are Required for Interferon (IFN)-{gamma}- and Tumor Necrosis Factor (TNF)-{alpha}-dependent Host Resistance to the Intracellular Pathogen, Toxoplasma gondii.
G. S. Yap and A. Sher (1999)
J. Exp. Med. 189, 1083-1092
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Interferon: Immunobiology and Clinical Significance.
E. R. STIEHM, L. H. KRONENBERG, H. M. ROSENBLATT, Y. BRYSON, and T. C. MERIGAN (1982)
Ann Intern Med 96, 80-93
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Interferon in Malaria.
M. WEINTRAUB (1970)
Ann Intern Med 73, 1045-1046
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Action of Interferon and Its Inducers Against Nonviral Infectious Agents.
J. Vilcek and R. I. Jahiel (1970)
Arch Intern Med 126, 69-77
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The Biological Significance of the Interferon System.
S. Baron (1970)
Arch Intern Med 126, 84-93
   Abstract »    PDF »
Interferon Induced by Plasmodium berghei.
K.-Y. Huang, W. W. Schultz, and F. B. Gordon (1968)
Science 162, 123-124
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