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Science 16 August 1968:
Vol. 161. no. 3842, pp. 706 - 708
DOI: 10.1126/science.161.3842.706
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Articles

Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe

George K. Aghajanian 1, Warren E. Foote 1, and Michael H. Sheard 1

1 Department of Psychiatry, Yale University School of Medicine, and Connecticut Mental Health Center, New Haven 06508

Units in areas of the midbrain rich in neurons containing serotonin respond to parenteral injections of d-lysergic acid diethylamide by a reversible cessation of spontaneous activity. The dose required is at or below threshold for gross behavioral effects. An inhibition of neurons containing serotonin after administration of d-lysergic acid diethylamide could account for the decreased metabolism of serotonin produced by this drug.


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