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Science 9 August 1968:
Vol. 161. no. 3841, pp. 589 - 590
DOI: 10.1126/science.161.3841.589
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Articles

Beta Thalassemia Trait: Detection at Birth

Yuet Wai Kan 1 and David G. Nathan 1

1 Hematology Research Laboratory, Department of Medicine, Children's Hospital Medical Center, Boston, Massachusetts, and Department of Pediatrics, Harvard Medical School

The synthesis of alpha, beta, and gamma chains in samples of cord blood was measured by the incorporation of leucine labeled with carbon-14 into these chains. In a newborn affected with beta thalassemia trait, the presence of one beta thalassemia gene was revealed on the 1st day of life by the lower specific radioactivity of the beta chain.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)