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Science 26 July 1968:
Vol. 161. no. 3839, pp. 377 - 379
DOI: 10.1126/science.161.3839.377
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Articles

Mitotic Apparatus: The Selective Extraction of Protein with Mild Acid

Thomas Bibring 1 and Jane Baxandall 1

1 Department of Molecular Biology, Vanderbilt University, Nashville, Tennessee 37203

The treatment of isolated mitotic apparatus with mild (pH 3) hydrochloric acid results in the extraction of less than 10 percent of its protein, accompanied by the selective morphological disappearance of the microtubules. The same extraction can be shown to dissolve outer doublet microtubules from sperm flagella. A protein with points of similarity to the flagellar microtubule protein is the major component of the extract from mitotic apparatus.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Colchicine-Inhibited Cilia Regeneration: Explanation for Lack of Effect in Tris Buffer Medium.
L. Margulis, S. Banerjee, and T. White (1969)
Science 164, 1177-1178
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Science. ISSN 0036-8075 (print), 1095-9203 (online)