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Science 26 July 1968:
Vol. 161. no. 3839, pp. 371 - 372
DOI: 10.1126/science.161.3839.371
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Articles

Nonrandomness of Translocations in Man: Preferential Entry of Chromosomes into 13-15/21 Translocaftons

Frederick Hecht 1, Milton P. Case 1, Everett W. Lovrien 1, James V. Higgins 1, Horace C. Thuline 2, and John Melnyk 3

1 Crippled Children's Division, University of Oregon Medical School, Portland 97201
2 Research Department, Rainier School, Buckley, Washington
3 Division of Metabolism (Genetics), Children's Hospital Los Angeles, California

Lymphocytes from 20 individuals with Down's syndrome due to 13-15/21 centric-fusion translocations were studied by autoradiography after continuous late labeling with tritiated thymidine. In no case was chromosome 13 involved; chromosome 14 was involved in 18 cases, and chromosome 15 in two cases. These results are similar to those from 13 previously studied cases and indicate that the entry of chromosomes 13-15 into translocations is nonrandom. This nonrandomness is not a simple function of chromosome size or shape, since chromosomes 13-15 are acrocentrics of similar size.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Chromosomal Variability in the D1 Trisomy Syndrome: Three Cases and Review of the Literature.
M. B. Taylor, R. C. Juberg, B. Jones, and W. A. Johnson (1970)
Arch Pediatr Adolesc Med 120, 374-381
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Science. ISSN 0036-8075 (print), 1095-9203 (online)