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Science 19 July 1968:
Vol. 161. no. 3838, pp. 265 - 266
DOI: 10.1126/science.161.3838.265
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Articles

Lymphoepithelial Tissues of the Intestine and Differentiation of Antibody Production

Daniel Y. E. Perey 1, Max D. Cooper 1, and Robert A. Good 1

1 Departments of Pediatrics and Surgery, University of Minnesota, Minneapolis

The antibody response of young rabbits to the injection of killed Brucella abortus was abolished by prior extirpation of intestinal lymphoepithelial tissues combined with lethal xirradiation and reconstitution with rabbit fetal liver cells. Extirpative surgery alone, like lethal x-irradiation and reconstitution without surgery, did not abolish this response. Intestinal lymphoepithelial tissues of rabbits apparently play a central lymphoid function and are responsible for the differentiation of the lymphoid cell line which produces specific antibody and immunoglobulins.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Clinical Review : The Human Gut and Immune Homeostasis: A Brief Survey of Current Concepts.
C. C. Roy and R. S. Dubois (1971)
Clinical Pediatrics 10, 275-281
   PDF »
Lymphopenic Agammaglobulinemia (Swiss Type) in Chicago: Autosomal Recessive Form.
R. B. Cole, A. D'Sousa, R. A. Good, R. A. Gatti, and J. R. Hoyer (1969)
Arch Pediatr Adolesc Med 118, 748-758
   Abstract »    PDF »


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