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Science 12 July 1968:
Vol. 161. no. 3837, pp. 173 - 175
DOI: 10.1126/science.161.3837.173
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Articles

Infectious Mononucleosis: Complement-Fixing Antibodies to Herpes-Like Virus Associated with Burkitt Lymphoma

Paul Gerber 1, Dorothy Hamre 2, Richard A. Moy 2, and Edith N. Rosenblum 3

1 Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland 20014
2 School of Medicine, University of Chicago, Chicago, Illinois 60637
3 Division of Biologics Standards

Complement-fixing antibodies to a herpes-like virus derived from a Burkitt tumor-cell line developed in each of 21 patients with infectious mononu-cleosis. These antibodies were absent in all serums before the patients became ill, appeared during the early phases of illness, and persisted for long periods of time. These antibodies are distinct from heterophile antibodies. None of the patients developed immune responses to herpes simplex, cytomegalo-, or reoviruses in the course of their illness. The data suggest that the development of complement-fixing antibodies to this herpes-like virus in these patients may be linked to infectious mononucleosis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Epstein-Barr Virus (Herpes-Type Virus) Antibodies in Connective Tissue Diseases.
D. A. Stevens, M. B. Stevens, G. R. Newell, P. H. Levine, and D. E. Waggoner (1972)
Arch Intern Med 130, 23-28
   Abstract »    PDF »
Etiologic Study of Nasopharyngeal Cancer.
D. Miller, J. M. Goldman, and M. L. Goodman (1971)
Arch Otolaryngol Head Neck Surg 94, 104-108
   Abstract »    PDF »
Concurrent Infectious Mononucleosis and Acute Leukemia.
M. H. Freedman, G. S. Gilchrist, and G. D. Hammond (1970)
JAMA 214, 1677-1680
   Abstract »    PDF »
Infectious Mononucleosis in Acute Leukemia with Rising Epstein-Barr Virus Antibody Titers.
W. L. DEARDORFF, P. GERBER, and W. R. VOGLER (1970)
Ann Intern Med 72, 235-240
   Abstract »    PDF »
Burkitt's Tumor.
P. P. CARBONE, C. W. BERARD, J. M. BENNETT, J. L. ZIEGLER, M. H. COHEN, and P. GERBER (1969)
Ann Intern Med 70, 817-832
   Abstract »    PDF »


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