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Science 5 July 1968:
Vol. 161. no. 3836, pp. 64 - 66
DOI: 10.1126/science.161.3836.64
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Articles

Prebiotic Synthesis: Phosphorylation in Aqueous Solution

R. Lohrmann 1 and L. E. Orgel 1

1 Salk Institute for Biological Studies, San Diego, California 92112

Formation of uridine-5'-phosphate from uridine and inorganic phosphate in aqueous solution is effected by the following condensing agents: cyanogen, cyanoformamide, cyanate, cyanamide, thioformate, ethylisocyanide, and a watersoluble carbodiimide. The yields are always small, even when a large excess of condensing agent is used. The cyclization of uridine-3'-(2')-phosphate occurs under the same conditions but in much greater yield.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Nucleoside Phosphorylation by Phosphate Minerals.
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Urea-Inorganic Phosphate Mixtures as Prebiotic Phosphorylating Agents.
R. Lohrmann and L. E. Orgel (1971)
Science 171, 490-494
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Template-Directed Synthesis with Adenosine-5'-phosphorimidazolide.
B. J. Weimann, R. Lohrmann, L. E. Orgel, H. Schneider-Bernloehr, and J. E. Sulston (1968)
Science 161, 387
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Science. ISSN 0036-8075 (print), 1095-9203 (online)