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Science 28 June 1968:
Vol. 160. no. 3835, pp. 1467 - 1469
DOI: 10.1126/science.160.3835.1467
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Articles

Behavioral Effects in Monkeys of Racemates of Two Biologically Active Marijuana Constituents

Carl L. Scheckel 1, Edward Boff 1, Philip Dahlen 1, and Terrence Smart 1

1 Department of Pharmacology, Hoffmann-LaRoche, Inc. Nutley, New Jersey 07110

Both dl-Dgr8- and dl-Dgr9-tetrahydrocannabinol produced marked alterations of behavior in rhesus and squirrel monkeys. Squirrel monkeys appeared to have visual hallucinations. Continuous avoidance behavior of squirrel monkeys was stimulated by both drugs, but high doses of dl-Dgr9-tetrahydrocannabinol also caused depression after the stimulant phase. Complex behavior involving memory and visual discrimination in rhesus monkeys was markedly disrupted by both drugs.


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