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Science 28 June 1968:
Vol. 160. no. 3835, pp. 1465 - 1467
DOI: 10.1126/science.160.3835.1465
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Articles

Hypersensitivity: Specific Immunologic Suppression of the Delayed Type

Michael Axelrad 1 and Donald A. Rowley 1

1 Department of Pathology, University of Chicago, Chicago, Illinois 60637

Delayed-type cutaneous hypersensitivity to sheep erythrocytes was induced in rats by intradermal injection of the antigen mixed with Freund's adjuvant; hypersensitivity was sustained by weekly injections. Either passive immunization with rat antiserum to sheep erythrocytes or intravenous injection of sheep erythrocytes partially suppressed induction of hypersensitivity; these procedures used together specifically and completely suppressed induction of hypersensitivity. Complete suppression was sustained by antigen given intravenously before each weekly injection of the mixture of antigen and adjuvant. These findings provide the rational basis of a simple method for prolonging survival of allografts with only the biological agents, antigen and antibody, of the immunological response.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Specific Suppression of Immune Responses.
D. A. Rowley, F. W. Fitch, F. P. Stuart, H. Kohler, and H. Cosenza (1973)
Science 181, 1133-1141
   Abstract »    PDF »
Rejection of Renal Allografts: Specific Immunologic Suppression.
F. P. Stuart, T. Saitoh, and F. W. Fitch (1968)
Science 160, 1463-1465
   Abstract »    PDF »


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