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Science 7 June 1968:
Vol. 160. no. 3832, pp. 1130 - 1132
DOI: 10.1126/science.160.3832.1130
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Articles

Toxoplasma gondii and Cytomegalovirus: Mixed Infection by a Parasite and a Virus

Albert H. Gelderman 1, Philip M. Grimley 1, Milford N. Lunde 2, and Alan S. Rabson 3

1 Pathologic Anatomy Branch, National Cancer Institute, Bethesda, Maryland 20014
2 Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases
3 Pathologic Anatomy Branch, National Cancer Institute

Human fibroblasts infected in vitro with cytomegalovirus are relatively resistant to infection by Toxoplasma gondii during the first 4 days of virus infection. After 5 days, however, the cytomegalovirus-infected cells become susceptible to the parasites. The toxoplasmas replicate in paracentral rosettes surrounded by host cell mitochondria. This growth configuration differs from that seen in human fibroblasts infected in vitro with toxoplasma only but resembles the pattern seen in doubly infected cells found in human necropsy tissue.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Toxoplasmosis in the Compromised Host.
J. RUSKIN and J. S. REMINGTON (1976)
Ann Intern Med 84, 193-199
   Abstract »    PDF »
The Uvea.
G. R. O'Connor (1974)
Arch Ophthalmol 91, 401-415
   PDF »
Coexistent Congenital Cytomegalovirus and Toxoplasmosis in a Stillborn.
S. D. E. Demian, W. H. Donnelly Jr., and G. R. G. Monif (1973)
Arch Pediatr Adolesc Med 125, 420-421
   Abstract »    PDF »


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