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Science 7 June 1968:
Vol. 160. no. 3832, pp. 1123 - 1124
DOI: 10.1126/science.160.3832.1123
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Articles

Tetrodotoxin: Effects on Fish and Frog Melanophores

Ryozo Fujii 1 and Ronald R. Novales 1

1 Department of Biological Sciences, Northwestern University, Evanston, Illinois 60201

Tetrodotoxin blocks the response of killifish melanophores to electrical stimulation of their melanin-aggregating nerves. The direct response of killifish or frog melanophores to hormones is not affected. Since there is no effect on melanin aggregation resulting from the release of adrenergic neurotransmitter in killifish melanophores, we conclude that tetrodotoxin acts by blocking nerve conduction.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A New Form of Inherited Red-Blindness Identified in Zebrafish.
S. E. Brockerhoff, J. B. Hurley, G. A. Niemi, and J. E. Dowling (1997)
J. Neurosci. 17, 4236-4242
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Science. ISSN 0036-8075 (print), 1095-9203 (online)