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Science 7 June 1968:
Vol. 160. no. 3832, pp. 1119 - 1121
DOI: 10.1126/science.160.3832.1119
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Articles

Resistance Changes in Lipid Bilayers: Immunological Applications

Per Barfort 1, Edward R. Arquilla 2, and Paul O. Vogelhut 3

1 Electronics Research Laboratory, University of California, Berkeley
2 Department of Pathology, School of Medicine, University of California, Los Angeles
3 Department of Electrical Engineering and Computer Sciences, University of California, Berkeley

The electrical resistance of a bimolecular lipid membrane in 0.1 molar NaCl decreases if antibody and complement are present on one side of the membrane and the homologous antigen is added to the other side. The reaction occurs within minutes and requires less than 0.1 microliter of antiserum.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)