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Science 17 May 1968:
Vol. 160. no. 3829, pp. 768 - 769
DOI: 10.1126/science.160.3829.768
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Articles

Gallamine (Flaxedil) and Synaptic Transmission in the Spinal Cord

Rudolph H. de Jong 1, Roberto Robles 1, and Ken-Ichii Morikawa 1

1 Departments of Anesthesiology and Pharmacology, University of Washington School of Medicine, Seattle 98105

A paralyzing dose of gallamine (Flaxedil) (1 to 2 milligrams per kilogram of body weight) has no effect on synaptic transmission in the cat's spinal cord. In spinal cats ventilated with oxygen, we stimulated a dorsal spinal root and recorded the compound ventral root potential. The reflex potential was not affected by 6.25 milligrams of gallamine per kilogram. Giving 12.5 milligrams of gallamine per kilogram had no significant effect on the monosynaptic spike height, but the polysynaptic response rose briefly to 12 percent above control. Increased magnitude of the polysynaptic response appeared related to a concomitant rise in blood pressure.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Science. ISSN 0036-8075 (print), 1095-9203 (online)