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Science 3 May 1968:
Vol. 160. no. 3827, pp. 539 - 541
DOI: 10.1126/science.160.3827.539
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Articles

Dihydroorotic Acid Dehydrogenase Activity of Human Diploid Cell Strains

Kuang-Dong Wuu 1 and Robert S. Krooth 1

1 Lawrence D. Buhl Center for Human Genetics, Department of Human Genetics, University of Michigan Medical School, Ann Arbor

A gene affecting the final two enzymes of uridylic acid biosynthesis does not affect a third, metabolically adjacent enzyme. Similarly, compounds that increase cellular activity for the affected enzymes do not increase activity for the third enzyme. The pyrimidine pathway can be subdivided into groups of concurrently responding enzymes. These groups may be smaller in human cells than they are in microbial cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Dihydroorotic Acid Dehydrogenase: Introduction into Erythrocyte by the Malaria Parasite.
R. S. Krooth, K.-d. Wuu, and R. Ma (1969)
Science 164, 1073-1075
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Science. ISSN 0036-8075 (print), 1095-9203 (online)