Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 3 May 1968:
Vol. 160. no. 3827, pp. 535 - 537
DOI: 10.1126/science.160.3827.535
Prev | Table of Contents | Next

Articles

Virus-Induced Hemolysis in Erythrocytes Deficient in Glucose-6-phosphate Dehydrogenase

Thomas F. Necheles 1 and Dov Gorshein 1

1 Departments of Pediatrics and Medicine, New England Medical Center Hospitals, Boston, Massachusetts 02111

Red cells from individuals deficient in glucose-6-phosphate dehydrogenase undergo increased autohemolysis when incubated in the presence of influenza-A virus. Normal red cells, but not those from individuals deficient in glucose-6-phosphate dehydrogenase, show increased activity of the hexose monophosphate shunt in the presence of the virus. This increase in shunt activity appears to be related to oxidation of cellular sulfhydryl groups.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Infectious Hepatitis with Excessive Hyperbilirubinemia and a Hemolytic Crisis in an 8-Year-Old Boy: His G6PD Deficiency Was an Aggravating Factor.
D. Fried, A. Gotlieb, and A. Roitman (1977)
Clinical Pediatrics 16, 482-483
   PDF »
Glucose-6-Phosphate Dehydrogenase Deficiency in Sickle-Cell Anemia: A Study in Adults.
M. H. STEINBERG and B. J. DREILING (1974)
Ann Intern Med 80, 217-220
   Abstract »    PDF »
Acute Viral Hepatitis, Glucose-6-Phosphate Dehydrogenase Deficiency, and Hemolytic Anemia.
H. R. Clearfield, J. I. Brody, and H. J. Tumen (1969)
Arch Intern Med 123, 689-691
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)