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Science 19 April 1968:
Vol. 160. no. 3825, pp. 309 - 311
DOI: 10.1126/science.160.3825.309
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Articles

Gas Chromatography for Detection of Viral Infections

B. M. Mitruka 1, M. Alexander 1, and L. E. Carmichael 2

1 Laboratory of Soil Microbiology, Department of Agronomy, Cornell University, Ithaca, New York
2 Veterinary Virus Research Institute, Cornell University

Gas chromatograms of sertim extracts of dogs inoculated with canine infectious hepatitis virus showed two metabolites not observed in uninoculated animals. Chromatograms of extracts of tissue cultures of dog kidney, inoculated with viruses causing canine hepatitis, herpes, and distemper, and a parainfluenza virus similar to simian virus-5, each showed two or more different metabolites. Two of the distinguishing products from cultures inoculated with hepatitis virus were chromatographically indistinguishable from those found in serums of the animals.


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