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Science 12 April 1968:
Vol. 160. no. 3824, pp. 206 - 207
DOI: 10.1126/science.160.3824.206
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Articles

A Cytoplasmically Transmitted, Diet-Dependent Difference in Response to the Teratogenic Effects of 6-Aminonicotinamide

A. C. Verrusio 1, D. R. Pollard 1, and F. C. Fraser 1

1 Human Genetics Sector, McGill University, Montreal, Canada

The frequency of congenital cleft palate produced by maternal treatment with 6-aminonicotinamide during pregnancy is lower in the C57BL/6J than in the A/J inbred mouse strain. In the C57BL/6J strain the frequency is lower when the mothers are maintained on Purina Lab Chow than when they are on Breeder Chow. A/J females do not show this effect of diet. There is a matroclinous reciprocal cross difference in frequency of induced cleft palate which persists in the back-cross when the F1 mothers are maintained on Lab Chow but not on Breeder Chow.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)