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Science 12 April 1968:
Vol. 160. no. 3824, pp. 204 - 206
DOI: 10.1126/science.160.3824.204
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Articles

Autoimmune Glomerulonephritis Induced in Sheep by Injections ofHuman Lung and Freund's Adjuvant

Raymond W. Steblay 1 and Ulrich Rudofsky 1

1 Departments of Pathology and Medicine, University of Chicago, Chicago, Illinois

Sheep immunized with human lung and Freund's adjuvant develop progressive glomerulonephritis with deposition of autoantibodies and complement in the glomerular basement membrane. This nephritis appears to be the first autoimmune disease induced by antigens that are not organspecific. By clinical and immunopathologic criteria, this nephritis appears identical to the nephritis induced in sheep by human glomerular basement membrane and greatly resembles certain nephritides of man, in particular, the nephritis in Goodpasture's disease.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Renal Involvement in Drug Abuse.
G. Eknoyan, F. Gyorkey, C. Dichoso, S. E. Hyde, P. Gyorkey, W. N. Suki, and M. Martinez-Maldonado (1973)
Arch Intern Med 132, 801-806
   Abstract »    PDF »
Goodpasture Syndrome: Dissociation From Antibodies to Glomerular Basement Membrane.
G. J. Beirne, W. L. Kopp, and S. W. Zimmerman (1973)
Arch Intern Med 132, 261-263
   Abstract »    PDF »
Goodpasture's Syndrome: Treatment With Nephrectomy and Renal Transplantation.
C. G. Halgrimson, C. B. Wilson, F. J. Dixon, I. Penn, J. T. Anderson, D. A. Ogden, and T. E. Starzl (1971)
Arch Surg 103, 283-289
   Abstract »    PDF »
Variant "Goodpasture's Syndrome"? The Need for Immunologic Criteria in Rapidly Progressive Glomerulonephritis and Hemorrhagic Pneumonitis.
J. S. MARTINEZ and P. F. KOHLER (1971)
Ann Intern Med 75, 67-76
   Abstract »    PDF »
Immunohistology of the Lung in Goodpasture's Syndrome.
G. J. BEIRNE, G. N. OCTAVIANO, W. L. KOPP, and R. O. BURNS (1968)
Ann Intern Med 69, 1207-1212
   Abstract »    PDF »


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