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Science 5 April 1968:
Vol. 160. no. 3823, pp. 81 - 82
DOI: 10.1126/science.160.3823.81
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Articles

Deamino-oxytocin: Inactivation by Plasma of Women in Labor

L. A. Branda 1, B. M. Ferrier 1, G. Archimaut 1, E. A. Marchelli 1, and B. Rucanski 1

1 Laboratorio de Polipéptidos, Servicio de Fisiología Obstétrica, Hospital de Clínicas, piso 16, Montevideo, Uruguay

Incubation of deamino-oxytocin with plasma obtained from women in labor reduced the potency of this analog of oxytocin when assayed on an isolated strip of mammary gland taken from a lactating rat. Plasmas of nonpregnant women had no detectable effect on this activity of deamino-oxytocin, and the effect of plasmas from women just previous to the beginning of labor was not significant. The original. activities of the incubated deamino-oxytocin solutions could be restored by treatment with hydrogen peroxide. The inactivation may be caused by reductive cleavage of the disulfide bridge of deamino-oxytocin, this bridge being reformed by oxidation.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)