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Science 29 March 1968:
Vol. 159. no. 3822, pp. 1467 - 1469
DOI: 10.1126/science.159.3822.1467
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Articles

Human Hormone Production in vitro

Roland A. Pattillo 1, George O. Gey 1, Eleanor Delfs 1, and Richard F. Mattingly 1

1 Finney-Howell Cancer Research Laboratory, Johns Hopkins Hospital, Baltimore, Maryland 21205, and Department of Gynecology-Obstetrics, Marquette School of Medicine, Milwaukee, Wisconsin 53226

A new in vitro hormone-synthesizing cell system, line BeWO, derived from human gestational choriocarcinoma, has been permanently established; a high degree of synthesis of functional hormone has been maintained for 18 months in tissue culture. Predominantly glycolytic metabolism, dependent on the level of glucose in the medium, has been observed. Many facets of placental and tumor-cell metabolism, growth, and differentiation are found in this unique multipotential cell.


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