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Science 22 March 1968:
Vol. 159. no. 3821, pp. 1351 - 1353
DOI: 10.1126/science.159.3821.1351
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Articles

Enzyme-Catalyzed Reactions of the Carcinogen N-Hydroxy-2-fluorenylacetamide with Nucleic Acid

C. M. King 1 and B. Phillips 1

1 Division of Cancer Research, Michael Reese Hospital and Medical Center, Chicago, Illinois 60616

A protein fraction obtained by gel filtration of a 105,000g supernatant of rat liver catalyzes three reactions of the hepatocarcinogen N-hydroxy-2-fluorenylacetamide with nucleic acid. Cofactor requirements and isotopic studies suggest that the reactive intermediates involved may be N-2-fluorenylhydroxylamine, and phosphate and sulfate esters of N-hydroxy-2-fluorenylacetamide.


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