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Science 26 January 1968:
Vol. 159. no. 3813, pp. 435 - 436
DOI: 10.1126/science.159.3813.435
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Articles

Parathyroid Hormone Production in vitro by Human Parathyroid Cells Transformed by Simian Virus 40

L. J. Deftos 1, A. S. Rabson 1, R. M. Buckle 1, G. D. Aurbach 1, and J. T. Potts Jr. 1

1 National Institutes of Health, Bethesda, Maryland 20014

Cells froma human parathyroid adenoma were infected with simian virus 40 and maintained through 13 subcultures in monolayer tissue culture. For more than 9 months, these "transformed" cells contimed to produce parathyroid hormone which was identified by radioimmunoassay and density-gradient ultra centrifugation.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)