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Science 22 December 1967:
Vol. 158. no. 3808, pp. 1590 - 1592
DOI: 10.1126/science.158.3808.1590
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Articles

Efficiency of the First Component of Complement (C'1) in the Hemolytic Reaction

Harvey R. Colten 1, Tibor Borsos 1, and Herbert J. Rapp 1

1 Biology Branch, National Cancer Institute, Bethesda, Maryland 20014

With the use of the first component of guinea pig complement (C'1) labeled in vivo with 14C-amino acids, we have obtained evidence that, under the conditions required for the assay of C'1, each molecule of C'1 capable of interaction with cell surface antigen-antibody complexes is capable of initiating the reaction sequence that leads to lysis of the cell.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)