Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 22 December 1967:
Vol. 158. no. 3808, pp. 1582 - 1585
DOI: 10.1126/science.158.3808.1582
Prev | Table of Contents | Next

Articles

Red Cells Coated with Immunoglobulin G: Binding and Sphering by Mononuclear Cells in Man

Albert F. LoBuglio 1, Ramzi S. Cotran 1, and James H. Jandl 1

1 Thorndike Memorial Laboratory, Second and Fourth (Harvard) Medical Services, Boston City Hospital, and Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts

Human monocytes, macrophages, and certain lymphocytes bind firmly to red cells coated with immunoglobulin G, whether or not it is acting as antibody. Monocyte binding is specific for cells coated with immunoglobulin G and is inhibited specifically by this immunoglobulin or its Fc-fragment in solution. Although not involving serum complement and not usually a prelude to erythrophagocytosis, this binding causes rapid morphological injury to red cells, as manifested by their sphering, increased osmotic fragility, deformation, and fragmentation. It is inferred that mononuclear cells have specific surface receptors for immunoglobulin G and that these provide a critical phase of the mechanism in vivo, whereby red cells or other particles coated with antibody are apprehended and destroyed.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Temporal differences in membrane loss lead to distinct reticulocyte features in hereditary spherocytosis and in immune hemolytic anemia.
L. Da Costa, N. Mohandas, M. Sorette, M.-J. Grange, G. Tchernia, and T. Cynober (2001)
Blood 98, 2894-2899
   Abstract »    Full Text »    PDF »
Immunohematologic Diseases.
L. J. Rosenwasser and B. Z. Joseph (1992)
JAMA 268, 2940-2945
   Abstract »    PDF »
Immunohematology.
A. D. Schreiber (1982)
JAMA 248, 1380-1385
   Abstract »    PDF »
Tumor surveillance: how tumors may resist macrophage-mediated host defense.
J Rhodes, M Bishop, and J Benfield (1979)
Science 203, 179-182
   Abstract »    PDF »
Pathophysiology of Immune Hemolytic Anemia.
M. M. FRANK, A. D. SCHREIBER, J. P. ATKINSON, and C. J. JAFFE (1977)
Ann Intern Med 87, 210-222
   Abstract »    PDF »
Autoimmune Hemolytic Anemia.
H. Chaplin and L. V. Avioli (1977)
Arch Intern Med 137, 346-351
   Abstract »    PDF »
Hemopoietic stem cells in human peripheral blood.
R. Barr, J Whang-Peng, and S Perry (1975)
Science 190, 284-285
   Abstract »    PDF »
Autoimmune Hemolytic Anemia.
J. V. Dacie (1975)
Arch Intern Med 135, 1293-1300
   Abstract »    PDF »
Red Blood Cell Osmotic Fragility After Aortic Valve Replacement.
E. Eyster, J. Rothchild, and O. Mychajliw (1972)
Arch Intern Med 130, 327-330
   Abstract »    PDF »
Plasmalemmal and Subsurface Complexes in Human Leukemic Cells: Membrane Bonding by Zipperlike Junctions.
F. T. Sanel and A. A. Serpick (1970)
Science 168, 1458-1460
   Abstract »    PDF »
Cytotoxic Effects of Leukocytes Triggered by Complement Bound to Target Cells.
P. Perlmann, H. Perlmann, H. J. Muller-Eberhard, and J. A. Manni (1969)
Science 163, 937-939
   Abstract »    PDF »
Human Monocytes: Distinct Receptor Sites for the Third Component of Complement and for Immunoglobulin G.
H. Huber, M. J. Polley, W. D. Linscott, H. H. Fudenberg, and H. J. Muller-Eberhard (1968)
Science 162, 1281-1283
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)