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Science 15 December 1967:
Vol. 158. no. 3807, pp. 1481 - 1482
DOI: 10.1126/science.158.3807.1481
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Articles

Segmented Polyurethane: A New Elastomer for Biomedical Applications

John W. Boretos 1 and William S. Pierce 1

1 National Institutes of Health, Bethesda, Maryland 20014

A segmented polyurethane elastomer, originally developed for elastic thread, is now being used for molded prostheses. Performance of this material when used for components of a heart-assist system warrants a thorough investigation of its effectiveness in a variety of biomedical devices.


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Neutrophil Adhesion on Polyurethanes Preadsorbed With High Molecular Weight Kininogen.
L.-Y. L. Yung, R. W. Colman, and S. L. Cooper (1999)
Blood 94, 2716-2724
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Biomedical Applications of Polyurethanes: A Review of Past Promises, Present Realities, and a Vibrant Future.
R. J. Zdrahala and I. J. Zdrahala (1999)
J Biomater Appl 14, 67-90
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Concerning thromboembolism associated with left ventricular assist devices.
D. R. Gross (1999)
Cardiovasc Res 42, 45-47
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Biodegradable Polyurethanes: Biodegradable Low Adherence Films for the Prevention of Adhesions after Surgery.
I. U. Rehman (1996)
J Biomater Appl 11, 182-257
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Small Caliber Vascular Grafts. Part II: Polyurethanes Revisited.
R. J. Zdrahala (1996)
J Biomater Appl 11, 37-61
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The Use of Silicone/Polyurethane Graft Polymers as a Means of Eliminating Surface Cracking of Polyurethane Prostheses.
L. Pinchuk, J.B. Martin JR, M.C. Esquivel, and D.C. Macgregor (1988)
J Biomater Appl 3, 260-296
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Heparinization of Medical Grade Polyurethanes.
R. Eloy, J. Belleville, M. C. Rissoan, and J. Baguet (1987)
J Biomater Appl 2, 475-519
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Artificial Hearts, Fractured Valves, and Other Problems With Medical Devices-Reply.
W. S. Pierce, G. Rosenberg, and D. B. Geselowitz (1985)
JAMA 254, 3307-3308
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Development of an Aliphatic Biomedical-Grade Polyurethane Elastomer.
M. Szycher, V. L. Poirier, and D. J. Dempsey (1983)
Journal of Elastomers and Plastics 15, 81-95
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Calcification inside artificial hearts: inhibition by warfarin-sodium.
W. Pierce, J. Donachy, G Rosenberg, and R. Baier (1980)
Science 208, 601-603
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The Artificial Heart: Progress and Promise.
W. S. Pierce, J. A. Brighton, J. H. Donachy, D. L. Landis, G. Rosenberg, G. A. Prophet, W. J. White, and J. A. Waldhausen (1977)
Arch Surg 112, 1430-1438
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Left Ventricular Bypass in the Dog: A Technique Employing Transthoracic Cannulation and a Paracorporeal Roller Pump.
S. Kazama, B. Chotiner, H. D. Metz, E. H. Lerner, J. A. Waldhausen, and W. S. Pierce (1972)
Arch Surg 105, 607-610
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