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Science 15 December 1967:
Vol. 158. no. 3807, pp. 1462 - 1463
DOI: 10.1126/science.158.3807.1462
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Articles

Imidazole: Fungitoxic Derivatives

Henry Tolkmith 1, James N. Seiber 1, Paul B. Budde 1, and Dorsey R. Mussell 2

1 Edgar C. Britton Research Laboratory, Dow Chemical Company, Midland, Michigan
2 Bioproducts Department, Dow Chemical Company

Study of several new types of fungitoxic derivatives of imidazole reveals that imidazoles substituted on the imine nitrogen atom are likely to be active if the substituent is electron-attracting, and if the atom connecting it to the imidazolyl moiety has tetrahedral geometry. Fungitoxicity is high with phosphinamidothionate and triarylmethyl groups as substituents. The presence of an asymmetric phosphorus atom in the substituent has no effect on fungitoxicity, but affects mammalian toxicity.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)