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Science 24 November 1967:
Vol. 158. no. 3804, pp. 1061 - 1064
DOI: 10.1126/science.158.3804.1061
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Articles

Murine Lymphoma: Augmented Growth in Mice with Pertussis Vaccine-Induced Lymphocytosis

M. Hirano 1, J. G. Sinkovics 1, C. C. Shullenberger 1, and C. D. Howe 1

1 Department of Medicine, University of Texas M. D. Anderson Hospital and Tumor Institute, Houston 77025

Injection of Bordetella pertussis vaccine caused an excessive lymphocytosis, associated with an augmented growth of a lymphoma cell homotransplant in mice. A markedly impaired reactive cell proliferation was revealed in the spleens of the vaccine-pretreated mice after stimulation with phytohemagglutinin or Freund's complete adjuvant.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Hemophilia: Role of Organ Homografts.
T. L. Marchioro, C. Hougie, H. Ragde, R. B. Epstein, and E. D. Thomas (1969)
Science 163, 188-190
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Science. ISSN 0036-8075 (print), 1095-9203 (online)