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Science 24 November 1967:
Vol. 158. no. 3804, pp. 1057 - 1058
DOI: 10.1126/science.158.3804.1057
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Articles

Angiostrongylus cantonensis: Proof of Direct Transmission with Its Epidemiological Implications

Donald Heyneman 1 and Boo-Liat Lim 1

1 International Center for Medical Research and Training (Hooper Foundation), Institute for Medical Research, Kuala Lumpur, Malaysia

Infective larvae of the rat lungworm Angiostrongylus cantonensis, presumed cause of human eosinophilic meningoencephalitis, are shed in mucus exuded by naturally infected Malayan slugs (Microparmarion malayanus). Larvae passed by slug hosts were recovered from lettuce and produced normal infection in white rats. Lettuce sold in the local public market also yielded small numbers of infective larvae. Experimental evidence from rats suggests that the local human population, exposed to repeated low-level infections, may become immunized against the rare massive exposure and against clinical disease that might otherwise result after ingestion of heavily infected raw mollusks.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
PCR-Based Detection of Angiostrongylus cantonensis in Tissue and Mucus Secretions from Molluscan Hosts.
Y. Qvarnstrom, J. J. Sullivan, H. S. Bishop, R. Hollingsworth, and A. J. da Silva (2007)
Appl. Envir. Microbiol. 73, 1415-1419
   Abstract »    Full Text »    PDF »
Cathepsin B Homologue at the Interface between a Parasitic Nematode and Its Intermediate Host.
M. S. Duffy, D. K. Cevasco, D. S. Zarlenga, W. Sukhumavasi, and J. A. Appleton (2006)
Infect. Immun. 74, 1297-1304
   Abstract »    Full Text »    PDF »
Food-borne parasitoses in Malaysia: epidemiological assessment and research needs.
K. Chandra Shekhar (1995)
Perspectives in Public Health 115, 178-185
   Abstract »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)